The Museum is conveniently located on the historic Park Blocks in the center of downtown Portland, which is easy to get around by public transit or on foot. The Portland Business Alliance has installed way-finding signs which direct you to the cultural district, where the Museum is located.

The Willamette River divides the City of Portland into east and west districts. The Portland Art Museum, located at 1219 SW Park Avenue, is roughly 12 blocks south of West Burnside Street and nine blocks west of the Willamette River. (Park Avenue is the same as 9th Avenue). The Museum is bounded by SW Park Avenue to the east, 10th Avenue to the west, Jefferson Street to the south, and Main Street to the north.